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KMID : 0358420090520121239
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Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 12 p.1239 ~ p.1244
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Prenatally diagnosed agenesis of corpus callosum
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Kim Gwang-Jun
Lee Eun-Sil
Lee Eun-Ju
Han Seung-Su
Lee Sang-Hoon
Kim Dong-Ho
Lee Jung-Ju
Yun Sin-Weon
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Abstract
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Objective: To report the clinical characteristics of the fetuses with agenesis of corpus callosum (ACC) diagnosed by prenatal ultrasonography.
Methods: Between 1998 and 2007, total twenty-two cases of ACC were identified. All cases were diagnosed by the direct evaluation of the corpus callosum using the ultrasonograpy with or without 3D multi-slice technique and color Doppler. Postnatal work-up was done by MRI or autopsy.
Results: The median gestational week was 26 weeks (19 to 34 weeks). The most common abnormal ultrasonographic finding was ventriculomegaly, shown in 19 (86.3%) of 22 cases. Absent cavum septum pellucidum and dilated upward displacement of third ventricle were also shown in 18 (81.8%) and 15 (68.2%) of 22 cases, respectively. Postnatal work-up performed in 9 cases (4 live-born babies and 5 still births) additionally confirmed the associated anomalies in three cases including a heart defect, an Aicardi syndrome, and trisomy 18.
Conslusion: The analysis of 22 cases presented in this report provides the precise materials to understand ACC. Targeted ultrasonographic evaluation may be helpful for prenatal diagnosis of ACC but has the limitation in differentiation of an isolated ACC from complex defect. To solve this limitation, therefore, the meticulous prenatal work-up and counseling would be needed.
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KEYWORD
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Agenesis of corpus callosum, Prenatal diagnosis
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